GREATER MONTRÉAL Life Sciences & Health Tech hub

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1 GREATER MONTRÉAL Life Sciences & Health Tech hub Christelle Fasano, PharmD Director, Business Development Life Sciences & Health Technologies Foreign Investments

2 01 Life sciences: a strategic sector for the province of Quebec

3 A STRONG SUPPORT TO FOSTER INNOVATION IN QUEBEC Life Sciences strategy Research and Innovation strategy Digital Strategy Advanced manufacturing (biomanufacturing) More than $ 1,7 B Source: Minisitry of Economy, Science and Innovation, Quebec,

4 GREATER MONTREAL, A STRATEGIG LOCATION IN NORTH AMERICA MONTRÉAL VANCOUVER TORONTO CHICAGO BOSTON NEW YORK LOS ANGELES SAN DIEGO *Source: Life Sciences strategy, Quebec, 2017 WASHINGTON Among the main east coast life sciences cluster By 2027: be one of the five largest North American hubs in Life Sciences & Health Technologies* 4

5 02 A unique interconnected & collaborative ecosystem

6 Province of Quebec ,000 jobs (80% concentrated in Montreal) +650 companies LIFE SCIENCES AND HEALTH TECHNOLOGIES 6

7 SNAPSHOT OF FOREIGN COMPANIES THAT HAVE CHOSEN THE GREATER MONTREAL The Life Sciences and Health Technologies Cluster 7

8 A GROWING CRITICAL MASS OF INNOVATIVE COMPANIES (BIO-PHARMA, MEDTECH, AI, DIGITAL) Interactive map - 8

9 MAJOR HUBS TO BOOST BUSINESS PARTNERSHIPS INNOVATION DISTRICT Multi-tenant hub specialized in the development of Small molecules and Biologics & Vaccines 9

10 A STRONG SUPPORT FROM VENTURE CAPITAL IN QUEBEC AmorChem CTI Life Sciences Lumira Capital II Sanderling Ventures TVM Capital Life Science Versant Ventures Emerillon Capital Teralys capital Caisse de dépôt et placement du Québec (CDPQ) Fonds de Solidarité FTQ BDC April 2016: DalCor Pharmaceuticals completes $150 M financing Proceeds to fund Phase 3 Trial of Dalcetrapib in Genetically Distinct Patients with Acute Coronary Syndrome October A strong come back of biotechs in Quebec 4 companies recently raised more than $380M: Repare ($87M), Clementia ($177M), Milestone ($70M) et PreciThera ($46M) Source: Fonds de solidarité FTQ 10

11 WORLD-RENOWNED SCIENTIFIC EXCELLENCE RECENT MAJOR INVESTMENTS IN CUTTING-EDGE INFRASTRUCTURES McGill University Health Centre (MUHC) CHU Sainte-Justine, Mother & child university hospital center Centre hospitalier de l Université de Montréal (CHUM) Reputed for our collaborative approach (Research Industry Government)

12 INTERNATIONALLY-ACCLAIMED FIELDS OF EXPERTISE Oncology Cardiovascular and metabolic diseases Neuroscience and mental health Infectious diseases Aging Cellular therapy and regenerative medicine Precision medicine (genetics, genomics and proteomics) Medical Imaging and cytometry Big Data and Artificial intelligence 12

13 EXAMPLES OF FLAGSHIP PROGRAMS TO ACCELERATE, DISCOVERY, DEVELOPMENT AND COMMERCIALIZATION Transforming early scientifc innovations into business partnership opportunities Accelerating discovery and commercialization of highly innovative therapies in oncology by strong partnerships with industry Extensive oncology research network Centre of Excellence in Precision Therapeutics One-stop shop for the development, translation and commercialization of ground-breaking cancer immunotherapies treatments Quebec s Experts Unite to Offer Excellence in Early Clinical Research NEOMED IRICoR Q-CROC EXACTIS C3i CATALIS Transdisciplinary and intersectoral open innovation ecosystem or living lab To develop next generation medical technologies Development of breakthrough tools and technologies that enhance biopharmaceutical R&D productivity Consortium for Industrial Research and Innovation in Medical Technology Accelerator for medical technology companies Space that transforms the projects of tech entrepreneurs into business success stories Transmedtech Institute CQDM MEDTEQ CTS CENTECH 13

14 KEY EXPERTISE FOR THE HEALTH INDUSTRIES FUTURES ALL IN A SINGLE PLACE ++++ Province of Quebec 56,000 jobs (80% concentrated in Montreal) +650 companies Bio-pharmaceuticals LIFE SCIENCES AND HEALTH TECHNOLOGIES 19 Artificial intelligence Medical technologies Digital health 14

15 Life Sciences &Health Tech hub: Click here to see the microsite + video Artificial intelligence: click here to see the microsite + video

16 03 Highly qualified pool of talents

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18 04 Advantageous cost structure for business and life

19 Greater Montreal Greater Montréal COST ADVANTAGE 19

20 Sectors: Aircraft Parts, Food Processing, Auto Parts, Specialty Chemicals, Electronics Assembly, Advanced Batteries, Medical Device Manufacturing, Metal Machining, Pharmaceutical Products, Plastic Products, Precision Components, Telecom Equipment, Video Game Production, Software Development, Bomedical R&D, Clinical Trials Management, Electronic System Development/Tests, International Financial Services, Shared Services Center. Source: Competitive Alternatives KPMG, 2017 LOW OPERATING COST TOTAL OPERATING COSTS FOR AN AVERAGE OF 19 ACTIVITY SECTORS (MONTRÉAL = 100) 20 largest metropolitan areas in North America, 2017 Montréal = 100 RUNNING A BUSINESS COSTS LESS IN GREATER MONTRÉAL THAN IN ANY OTHER MAJOR NORTH AMERICAN METROPOLITAN AREA 1 st rank: The most competitive operating costs of North America s 20 largest metropolitan areas In the life sciences and medical devices industries, the cost advantage over the average of North America s 19 other largest metropolitan areas is more than 23% Total costs comprise: labor costs, facility costs, transportation costs, utility costs and taxes.

21 INCENTIVES AVAILABLE IN QUEBEC MAJOR AND INNOVATIVE PROJECTS ESSOR, Créativité Québec, Major Investment Projects (included bio manufacturing), Economic Development Canada program, Strategic Innovation Fund, Hydro- Québec economic development rate MANY QUÉBEC TAX CREDITS ARE REFUNDABLE A COMPANY COULD RECEIVE THE VALUE OF ITS TAX CREDIT EVEN IF IT HAS NO TAX PAYABLE. INDUSTRY CREDITS multimedia titles, e-business development, international financial centres, film production services LABOUR DEVELOPMENT financial aid for training RESEARCH AND DEVELOPMENT tax credit for research and development (Québec and federal), Industrial Research Assistance Program (IRAP) and tax holiday for foreign researchers and experts 21

22 Greater Montréal COST ADVANTAGE 22

23 Greater Montréal COST ADVANTAGE 23

24 AFFORDABLE HOUSING, 30% LESS EXPENSIVE THAN TORONTO AND 55% LESS THAN BOSTON HOUSING COSTS (MONTRÉAL = 100) Selection of metropolitan areas, 2017 Montréal Houston Toronto Chicago Miami Los Angeles NORTH AMERICAN EFFICIENCY + EUROPEAN CHARM: Greater Montréal offers workers and their families the best of two worlds According to The Economist, Montréal is the 2 nd best city in the world for living. Amongst the main North American metropolitan areas, Montréal has the best domestic purchasing power in Canada, 3 rd in North America. Washington Boston New York City San Francisco Source: Expatistan, 2017; The Economist Intelligence Unit, 2015; Prices & Earnings 2015, UBS,

25 05 Montreal International: your strategic partner since 1996

26 MONTRÉAL INTERNATIONAL AT A GLANCE A CATALYST FOR FOREIGN INVESTMENT The Greater Montréal investment promotion agency since 1996 A single point of access to a series of personalized, free and confidential services 70 specialists (economists, lawyers, communications,..) to assist you in setting up or expanding your business This includes a group of territorial (EU, Americas, Asia) and sectorial experts (Life Sciences & Health Technologies - ICT - AI - Aerospace)

27 STRATEGIC PARTNERSHIPS OR INTERNATIONAL EXPANSION IN MONTREAL We can assist you through the whole process Exploratory phase Project definition Implementation Navigate through the LSHT ecosystem Organize a tailored visit in Montréal Outline the strategic options of the project Assist you to structure your project Identify available incentives if relevant Introduce you to the right partners Assist you with international mobility (work permit) and talent acquisition Public announcement «After care» LSHT: Life Sciences and Health Technologies

28 CHRISTELLE FASANO, PHARM D Director, Business Development, Life Sciences & Health Tech Foreign investments Montréal International t c christelle.fasano@mtlintl.com MONTRÉAL INTERNATIONAL 380 Saint-Antoine Street West Suite 8000 Montréal, Québec H2Y 3X7 t f