(12) Ulllted States Patent (10) Patent N0.: US 8,459,793 B2 de Juan, Jr. et al. (45) Date of Patent: Jun. 11, 2013
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1 US B2 (12) Ulllted States Patent (10) Patent N0.: US 8,459,793 B2 de Juan, Jr. et al. (45) Date of Patent: Jun. 11, 2013 (54) CONFORMABLE THERAPEUTIC SHIELD (58) Field of Classi?cation Search FOR VISION AND PAIN USPC l/200i246 See application?le for complete search history. (75) Inventors: Eugene de Juan, Jr., San Francisco, CA (US); Cary J. Reich, Los Gatos, CA (56) References Clted (US); Yair Alster, Palo Alto, CA (US); K. Angela Macfarlane, Woodside, CA US- PATENT DOCUMENTS (US); Doug Rimer, Los Altos Hills, CA 2,641,161 A 6/1953 Silverstein (US); Douglas Sutton, Paci?ca, CA 3,246,941 A 4/1966 MOSS (US); Dean Carson, Mountain View, CA (Continued) (US); Enrique Barragan, Monterrey (MX); M an Clarke, M enl 0 Park, CA FOREIGN PATENT DOCUMENTS (US); Ashley Tuan, Menlo Park, CA CA C 5/1995 (US); Brian Levy, New York, NY (US) DE A1 5/1983 (Continued) (73) Ass1gnee: NexlsVlslon, Inc., Menlo Park, CA (US) OTHER PUBLICATIONS ( * ) Notice: Subject to any disclaimer, the term OfthiS International Search Report and Written Opinion of the International patent is extended or adjusted under 35 SearchingAuthority for PCT ApplicationNo.PCT/US20l0/053975, U.S.C. 154(b) by 0 days. mailed Feb. ll, 201 l, 30 pages. (21) Appl. No.: 13/615,111 (Continued) - Primary Examiner * Mohammed Hasan 22 F1 d: S ( ) 1 e 61) (74) Attorney, Agent, or Firm * Kilpatrick Townsend & (65) Prior Publication Data Stockton LLP US 2013/ A1 Jan. 31, 2013 (57) ABSTRACT A conformable covering comprises an outer portion With rigidity to resist movement on the cornea and an inner portion Related U s Apphcatlon Data to contact the cornea and provide an environment for epithe (63) Continuation of application No. 13/503,842,?led as regenerenell The Inner P of the eevenng ean be application NO_ pct/us2010/ on Oct 25 con?gured 1n many Ways so as to conform at least part1ally to 2010 an ablated stromal surface so as to correct v1s1on. The con formable inner portion may have at least some rigidity so as to (60) PIN/ appheatlen N0~ 61/279,613,?led 011 OCI- smooth the epithelium such that the epithelium regenerates 23, 2009, PFOViSiOIlal application N0~ 61/322,206, rapidly and is guided With the covering so as to form a smooth?led On Apr. 8, layer for vision. The inner portion may comprise an amount of rigidity Within a range from about l><l0-4 Pa*m3 to about (51) Int- Cl- 5><l0-4 Pa*m3 so as to de?ect and conform at least partially A61B 3/14 ( ) to the ablated cornea and smooth an inner portion of the A61B 3/00 ( ) ablation With an amount of pressure When de?ected. (52) US. Cl. USPC /207; 351/ Claims, 66 Drawing Sheets
2
3 US 8,459,793 B2 Page / A1 10/2006 Dahi WO 2005/ A2 12/ / A1 10/2006 Marmo WO 2006/ A2 3/ / A1 11/2006 Legerton WO 2006/ A3 3/ / A1 11/2006 Dahi WO 2006/ A1 11/ / A1 12/2006 Dahi WO 2007/ A1 1/ / A1 12/2006 Meyers et al. WO 2007/ A1 4/ / A1 1/2007 Dahi WO 2007/ A2 5/ / A1 1/2007 Peyrnan WO 2007/ A3 5/ / A1 2/2007 Phelan et al. WO 2009/ A1 5/ / A1 3/2007 Muckenhirn WO 2006/ A2 10/ / A1 5/2007 Chen WO 2006/ A3 10/ / A1 10/2007 Dootjes et al. WO 2009/ A2 12/ / A1 10/2007 Shiuey WO 2010/ A1 5/ / A1 11/2007 Legerton WO 2011/ A1 4/ / A1 2/2008 Palanker et al. WO 2011/ A1 4/ / A1 3/2008 Meyers et al. WO 2012/ A1 5/ / A1 11/2008 Meyers et al. 2009/ A1 4/2009 Lai et al /206 OTHER PUBLICATIONS 832: 2: 3%: International Preliminary Report on Patentability for PCT Applica 2010/ A1 3/2010 Hibino International Search Report and Written Opinion of the International 2010/012g224 A 1 5/201() Legenon Searching Authority for PCT Application No. PCT/US2010/ , 2010/ A1 6/2010 Berke mailed Mill 1, 2011, 18 pages~ 2010/ A1 8/2010 Benrashid et al. International Preliminary Report on Patentability for PCT Applica 2010/ A1 10/2010 Legerton et al. tion No. PCT/US2010/053854, dated Apr. 24, 2012, 13 pages / A1 8/201 1 De Juan, JR et a1~ International Search Report and Written Opinion of the International 2012/ A1 5/2012 Legerton Searching Authority for PCT Application N0. PCT/US2009/002166, 2012/ A1 5/2012 Back _ mailed NOV 19, 2009, 13 pages 2012/ A1 7/2012 Matsushlta et 31' International Preliminary Report on Patentability for PCT Applica tloil NO.- PCT/US2009/002I66, dated Oct. 5, 2010, 5 pages. International Search Report for PCT/U S201 1/ 57755, mailed on Feb. EP A2 12/1981 7, 2012, 3 pages 5; é International Search Report and Written Opinion of the International GB A 5/1983 Searching Authority for PCT Application No. PCT/US2012/035050, W0 90/ Al H990 mailed Oct. 3, 2012, 12 pages. W0 95/l3764 A1 5/1995 Bissen-Miyajima et al., Role of the endothelial pump in?ap adhe WO 96/27816 A1 9/1996 sion after laser in situ keratomileusis, J Cataract Refract Surg. Sep. WO 97/19381 Ai 5/ ;30(9)1PP~ W0 98/ A1 1/ 1998 Bausch & Lomb Boston Materials & Solutions Product Guide, WO 99/30560 A1 6/ , 38 pages total, September. WO 99/43354 A2 9/ 1999 SynergEyes, Inc., SynergEyes A Practitioner Training, retrieved W0 99/ A3 9/1999 from the Internet: < WO 99/46631 A1 9/1999 synergeyesaipresentation.pdf>, 52 pages, Sep. 1, WO 00/09042 Al 2/2000 SynergEyes, Inc., SynergEyes A, [package insert, P/N WO 01/68082 A1 9/2001 WO 02/ Ai 9/2002 Rev 1] 12 Pages Sep' '. W0 03/ Al SynergEyes, Inc., Product Overview of CLEARKONE and WO 2004/ A1 11/2004 synergeyescom/indexhtml on May 29, 2012, 5 pages. WO 2004/ A2 12/2004 WO 2005/ A2 9/2005 * cited by examiner
4 US. Patent Jun. 11,2013 Sheet 1 0f 66 US 8,459,793 B2 FIG. 1
5 US. Patent Jun. 11,2013 Sheet 2 0f 66 US 8,459,793 B2 FIG. 1-1A
6 US. Patent Jun. 11,2013 Sheet 3 0f 66 US 8,459,793 B2 FIG. 1-1 B
7 US. Patent Jun. 11,2013 Sheet 4 0f 66 US 8,459,793 B2 12R 12RP 20D 11 / A FIG. 1-1C
8 US. Patent Jun. 11,2013 Sheet 5 0f 66 US 8,459,793 B2 FIG. 1-2A
9 US. Patent Jun. 11,2013 Sheet 6 6f 66 US 8,459,793 B2 12RP R 20B 20 20B 14 FIG. 1-2B
10 US. Patent Jun. 11,2013 Sheet 7 0f 66 US 8,459,793 B2 FIG. 1A
11 US. Patent Jun. 11,2013 Sheet 8 0f 66 US 8,459,793 B2 100 FIG. 1A1
12 US. Patent Jun. 11,2013 Sheet 9 0f 66 US 8,459,793 B [100 FIG. 1B1 12OP 12R 12 R12 FIG. 1B2
13 US. Patent Jun. 11,2013 Sheet 10 0f 66 US 8,459,793 B2 FIG. 152A 120 FIG. 152B
14 US. Patent Jun. 11,2013 Sheet 11 0f 66 US 8,459,793 B f OP 1614 / 12 [10 FIG. 152C
15 US. Patent Jun. 11,2013 Sheet 12 0f 66 US 8,459,793 B R1 FIG. 1C FIG. 1C1
16 US. Patent Jun. 11,2013 Sheet 13 0f 66 US 8,459,793 B2 FIG. 1C1A
17 US. Patent Jun. 11,2013 Sheet 14 0f 66 US 8,459,793 B2 110MB 110M 11OM1 1OOL3 1OOL1 130 / 120 FIG. 1C2
18 US. Patent Jun. 11,2013 Sheet 15 0f 66 US 8,459,793 B2 20D FIG. 1C2A
19 US. Patent Jun. 11,2013 Sheet 16 6f 66 US 8,459,793 B2 FIG. 1D
20 US. Patent Jun. 11,2013 Sheet 17 0f 66 US 8,459,793 B2 000 O0 ooooooooo, o 8.0% :0: o: 000 0:02: 00 FIG. 1E FIG. 1F
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