Jim Mangione June, 2017

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1 Jim Mangione June, 2017

2 Placeholder for Cholesterol VR Video PLAY VIDEO FROM: 00:35 01:42 2

3 This presentation outlines a general technology direction. Pfizer Inc. has no obligation to pursue any approaches outlined in this presentation or to develop or use any functionality mentioned in this presentation. The technology strategy and possible future developments are subject to change and may be changed at any time for any reason without notice. The views and opinions expressed in this presentation and any related discussion(s) are solely those of the individual presenter(s) and may not express the views of and opinions of Pfizer Inc. 3

4 Funding Snapshot For U.S. Healthcare Technology Investments Startup Health Insights

5 Startup Health Insights Top 10 Most Active Subsectors in Digital Health Investments 5

6 Smart Homes elf-driving Cars Smart Cars Smart Cities Google Glasses 3D Printing Blockchain Drones NLP Sensors Big Data Cost of Digitization Bitcoin AeroMobil Connectivity Configurable Smart Phones Compliance Virtual Reality Data Mining Cloud Privacy AI Robotics intelligence Connected Health IoT IoCT Data Science Social Network Convergence of Technology Machine Learning In today s environment we observe the following trends Rapid pace of technological innovation

7 Mixed Realities PTSD Treatments Use of VR plus audio and even scent for exposure therapy in post-traumatic stress patients.. Physical Therapy Virtual, in-home therapy sessions using gesture control and real-time intelligent feedback. Pain Therapy Diverting patient s focus on procedures or recovery processes and reducing pain. 7

8 Transportation Delivering vaccinations and doctors to your doorstep Healthcare professionals delivering vaccinations and checkups at your home. Delivering patients to investigators The opportunity to provide medical transportation using economical services that scale broadly. Autonomous Delivery Looking into the future how will this disrupt medical transportation and drug delivery? 8

9 Consumer Health Emerging Technologies Image owned by Withings Connected Device Platforms Consumer-grade connected health platforms are emerging, however still proprietary and not completely open Image owned by PillDrill Medical Adherence Patients have a wide range of options to be reminded to take their meds. How sticky are these really? All this other connected STUFF From pain relief to air quality, thermometers and multifunction physiological sensors 9

10 Convergence of Connected Home & Health SMART HOME Garage Irrigation Doorbell Appliances Fridge TV Locks Music Weather Fitness Digital Assistant Motion Presence Humidity Conversational UI Pressure Gaming Lights Blinds Temperature Contact Sensors Motion Alerts Cameras Scale BP Pulse Ox ECG Mobile Heartrate UV Sensors Sleep Sensors Glucose Monitor VR PHR Stethoscope Inhaler Pillboxes & Caps Fitness Bands CONNECTED HEALTH Air Quality Spirometer EEG Headbands 10

11 Medical Adherence and Beyond The Reminder App Connected Sharps Container Photographing Pills taken Patches that remind you Pill dispensers Gamification Virtual and Live Coaching ADHERENCE TRENDS Incentives and Rewards Personalized Interventions 11

12 Conversational AI and Connected Health Enabling New Capabilities Alex, did I take my meds today? You removed 2 pills from your bottle at 9:10am

13 Intelligent Assistants Engaging Patients in Smarter Ways ChatBots Becoming Smarter and More Prolific Natural Language Processing and and Voice Recognition are commodity platforms nows, enabling more focus on contextual domain knowledge Personalized Insights Lead to Behavioral Change Using machine learning techniques and diverse data points, predictive models can provide patients smart recommendations to live healthier lives The Human Connection Apps may start with a virtual assistant, but many will bring a real-life Healthcare Professional into the conversation if needed.

14 Robotic Assistants At-Home Companions In-Hospital Assistants Distraction From Therapy Catalia Health s Mabu engages with patients in their homes to aid in disease management Xiaopang can provide patient education and assistance through voice and projection technology Pepper and NAO can take video consents and help with anxiety and stress during adolescent medical procedures

15 Wearables: What s Next? Expanding array of sensors & algorithms are creating new capabilities Pressure / Stretch Machine Learning Non-Invasive Glucose Levels EEG Biochemical afib Detection EKG Predictions Bio Authentication Making bands and fabrics smarter PRO options are growing beyond clinical grade devices

16 Beyond Wearable Sensors: Smart Exoskeletons SNU (Seoul National University) Pneumatic Hand Exoskeleton helps impaired patients perform daily tasks Soft robotic technologies use actuators for artificial muscles and tendons and may also leverage EEG and other embedded sensors for automating control. Other human-robotic assistants are larger in scale, such as the Active Pelvis Orthosis exoskeleton, which can detect a person falling and attempt to apply a counter-force to correct their stance.

17 Healthcare Record Transmission Today Jan, 2014 EHR App EHR App Jan, 2014 Visit Jun 2015 Blood Work Jan, 2014 Blood Work 2 Day Request Patient Blood Work 17

18 Healthcare Record Transmission Using Blockchain PHR App Jan, 2014 Jan, 2014 Jun 2015 Visit Bld Wrk Bld Wrk Instant Request 18

19 To Summarize: Keep Looking For New Opportunities To Engage Our Patients! Go to where the patient is: Home, Office, Vehicle Look at new ways to utilize existing technologies Identify companies that are personalizing digital health Follow The Money: See where VC s are investing their capital 19

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