2012 North American Laboratory Researchers Choice: Future Market Leader of Digital PCR Technology Award

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1 2011 South African Data Centre Green Excellence Award in Technology Innovation Cybernest North American Laboratory Researchers Choice: Future Market Leader of Digital PCR Technology Award 2011 Frost & Sullivan 1 We Accelerate Growth

2 2012 North American Laboratory Researchers' Choice: Future Market Leader of Digital PCR Technology Award Survey Results Award Recipient: Bio-Rad QX100 Droplet Digital PCR Based on Frost & Sullivan s independent research, 2012 Quantitative and Digital PCR Instrumentation and Consumables Purchasing Trends, Bio-Rad: QX100 Droplet Digital PCR emerges as the future leader in the digital PCR market segment among healthcare related laboratory decision makers in North America. Thus, Bio-Rad is recognized as the Future Market Leader of Digital PCR Technology in this dynamic market. Bio-Rad is the Future Leader in dpcr Market Segment, Winning Easily Over Nearest Competitors! If stated intentions materialize, Bio-Rad: QX100 Droplet Digital PCR will be a definite leader in the future in the dpcr market segment: over half of those who plan to install dpcr in the next 12 months intend to choose this brand. Survey Results (Continued) Source: Frost & Sullivan Laboratory researchers were asked to state, in their opinion, the advantages (if any) of digital PCR over real-time PCR. Approximately two-thirds of researchers mentioned advantages of digital PCR, among which sensitivity, reliability, and reproducibility were quite often stated.

3 Sample of verbatim comments: Smaller assay volumes, reproducible quantitation and faster results. High throughput might be a consideration. Laboratory manager, hospital or clinical laboratory Cheaper & easier to use with more reproducibility than qpcr. Laboratory manager, academic institution Price, cost of consumables, ease of use, precision and accuracy of measurements. Graduate student, academic institution The quantification of samples with low target quantity. Senior researcher, hospital or clinical laboratory The technique doesn`t need reference gene marker. Project manager, academic institution Number of users and technological improvements. Project manager, academic institution High sample volume and higher number of loci/targets. Principal investigator, academic institution dpcr is more precise. Senior researcher, academic institution More sensitivity and reliability. Post-doctoral fellow, private non-profit organization Low target number analysis, smaller volume requirements, speed, pathogen monitoring. Laboratory manager, academic institution Sensitivity and reproducibility, low signal to noise ratio. Staff scientist, academic institution What This Means Bio-Rad Digital PCR is an emerging and exciting technology generating much attention in the industry for its precision, reproducibility, and promising potential in diagnostic and pharmaceutical applications. Frost & Sullivan expects the dpcr instrumentation market to grow at a tremendous compound annual growth rate of 52.0 percent from 2011 to The high sensitivity of dpcr makes it ideal for a growing number of applications, including copy number variation, rare mutation detection, and absolute quantitation of nucleic acid sequences. As the industry develops new applications for the technology, making it more valuable to the user, adoption rates are expected to increase. Frost & Sullivan s survey indicates that Bio-Rad s QX100 Droplet Digital PCR system will emerge as the most popular digital PCR platform on the market. In this high growth, promising market, Bio-Rad s investment in digital PCR will prove fruitful as it emerges as the market leader.

4 Firmagraphics Job title or position Firmagraphics Principal investigator 24% Staff scientist 15% Post-doctoral fellow 14% Senior researcher 11% Laboratory director 8% Laboratory manager 7% Lab technician 5% Graduate student 5% Project leader/manager 3% Group leader 2% Department manager 1% Other (PhD student, coordinator) 4% Type of organization Academic/ Government 67% Biotech/Pharma 16% Hospital/Clinic 6% Other (cancer treatment and research facility, non-profit scientific R&D organization, consulting company) Country 11% United States 92% Canada 8% Percents might not sum to 100 because of rounding error. Source: Frost & Sullivan About Bio-Rad Bio-Rad, a publically-held family-run company based in Hercules, CA, and founded in 1952, provides a broad range of products across the life science research tools and clinical diagnostic markets. As one of the oldest companies in the industry, Bio-Rad thrives on its commitment to exceptional customer service and delivering high quality products with innovation, ease-of-use and value top-of-mind. With the company s acquisition of QuantaLife in October 2011, Bio-Rad added to its portfolio the most promising and highly touted digital PCR platform on the market. Now called the QX100 Droplet Digital PCR System, the technology allows for detection of nucleic acids at higher resolution and lower target levels than qpcr, making it an ideal platform for highly precise research applications and the development of very sensitive companion diagnostics. The instrument is receiving significant attention from pharmaceutical companies and cancer research laboratories as Bio-Rad ramps up adoption globally. The the QX100 Droplet Digital PCR System s accuracy, simple workflow,

5 affordability, and easy integration into the laboratory have set it apart from other digital PCR platforms on the market. By developing products that offer simple usability, functionality, performance, and value, Bio-Rad continues to earn new business and enjoy customer loyalty in the life sciences industry. With a market-leading platform and a strong reputation among researchers, Bio-Rad is poised for success in the cutting-edge digital PCR market and the ideal recipient of the Future Market Leader of Digital PCR Technology Award. Methods Frost & Sullivan surveyed healthcare related laboratory decision makers based in North America during August Award Description The Frost & Sullivan Choice Award is bestowed upon the company that has demonstrated excellence in one or more aspects of its operations. The Award recipient has distinguished itself through its proactive strategies that position it as an industry leader. More specifically, Award recipients are determined directly by survey respondents responses based upon their perceptions of the companies competing in a particular market segment. About Best Practices Frost & Sullivan Best Practice Awards recognize companies in a variety of regional and global markets for demonstrating outstanding achievement and superior performance in areas such as leadership, technological innovation, customer service, and strategic product development. Customer Research analysts conduct the survey research to identify best practices in the industry. About Frost & Sullivan Frost & Sullivan, the Growth Partnership Company, enables clients to accelerate growth and achieve best in class positions in growth, innovation, and leadership. The company's Growth Partnership Service provides the CEO and the CEO's Growth Team with disciplined research and best practice models to drive the generation, evaluation, and implementation of powerful growth strategies. Frost & Sullivan leverages 50 years of experience in partnering with Global 1000 companies, emerging businesses, and the investment community from more than 40 offices on six continents. To join our Growth Partnership, please visit

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