The Changing Face of Product and Process Development in the QbD Era. James Kraunsoe AstraZeneca Product Development UK/US
|
|
- Garey Berry
- 5 years ago
- Views:
Transcription
1 The Changing Face of Product and Process Development in the QbD Era James Kraunsoe AstraZeneca Product Development UK/US
2 Disclaimer The views and opinions expressed in the following PowerPoint slides are those of the individual presenter and should not be attributed to Drug Information Association, Inc. ( DIA ) (DIA), its directors, officers, employees, volunteers, members, chapters, councils, Special Interest Area Communities or affiliates, or any organization with which the presenter is employed or affiliated. These PowerPoint slides are the intellectual property of the individual presenter and are protected under the copyright laws of the United States of America and other countries. Used by permission. All rights reserved. Drug Information Association, DIA and DIA logo are registered trademarks or trademarks of Drug Information Association Inc. All other trademarks are the property of their respective owners.
3 Presentation outline Designing in R&D a manufacturing process for Operations What do Manufacturing require? Illustrate approach taken by R&D Use of appropriate p tools How to work smarter Case studies Examples for tablet products Summary and reflections
4 Requirements of manufacturing Operations driven by cost pressures and need to reduce waste This requires development of Lean/6 Sigma processes and supply chain Operations have 3 key requirements of R&D Robust and capable processes Defined eg, CpK for CQAs and controls >1.67 Operational flexibility Equipment type, scale, operating ranges Flexible or reduced control strategy Exemplify Ability to facilitate innovation and to tolerate variation Use of newer more innovative technology Eg, via a site transfer Natural variation eg, raw materials including API
5 Development Tools: Paper based Define Quality Target Pharmaceutical Profile Define critical quality attributes cf ICHQ8 Target for for a safe, efficacious and quality product Define process targets that define success wrt manufacturabilty Process metrics eg, Cpks Define Quality Risk Managment Reflect product and prior knowledge (or experience) Prioritise development activities Identifies sources of variation and develop the understanding to adapt Impact of equipment scale and type Changes to raw material grades, suppliers
6 Development Tools: Practical 8 12 Design of Experiments studies Prioritise variables by QRA Perform at small, pilot and large scale Evaluate formulation/materials and process Examples Water Amount (%w/w) IR tablets 1.25 Wet granulation Example of an evolving design Milling Reduced factorial design 0.75 Time (min) Mg stearate Amount (%w/w) No of revs Impeller tip speed (m/s) Low Milled granule SA (cm 2 /g) High
7 Development Tools: Practical Product and process characterisation Imaging NMR of tablets t Dissolution of modified release tablet Understanding the impact of raw materials and/or process on the dissolution rate of polymers Presence of inclusions in immediate release tablets Time Flow characterisation Understanding how material properties affect bulk flow of powders 90 - φ w ( ) 66 High cohesion Prosolv 64 Low adhesion 90HD Emocel Avicel Good flow PH102 properties 60 Avicel 58 PH101 L-HPC LH22 56 L-HPC LH11 54 HPC-LF Low cohesion 52 Poor flow High adhesion 50 properties FF c (-)
8 Development tools - Practical Process Analytical Technologies Particle size during granulation 1-21 um In-line use FBRM Monitoring of fine and larger particles with increasing water amount and time um Median um Time Granule moiture content during drying In-line NIR Single variable monitoring against 0.50 known moisture peak VAR_ :57 09:58 09:59 10:00 10:01 10:02 10:03 10:04 10:05 10:06 10:08 10:09 10:10 10:11 10:12 10:13 10:14 10:15 10:16 10:17 10:18 10:19 10:20 10:21 10:22 10:23 10:24 10:25 10:27 10:28 10:29 10:30 10:31 10:32 10:33 10:34 10:35 10:36 10:38 10:39 10:40 10:41 10:42 10:43 10:44 10:45 10:46 10:47 10:48 10:49 10:50 11:01 Objective: To confirm process is proceeding as intended Obs ID (DateTime)
9 Manufacturing: Operational flexibility Roller compaction model: Scale independence Empirical (from DOE) vs mechanisitic (from theory) Ribbon Porosity: 20 25% Throughput: > 17 kg/h Theoretical operating region Raw material characterisation Roller compaction model Experimental operating space: Full scale experiments Intermediate characterisation
10 Manufacturing: Managing variability In-process Granule Size Control for IR tablet intermediate Combined Feed Forward/Feed Back Loop STAGE 2: WET GRANULATION STAGE 3: WET MASS DE- LUMPING STAGE 4: DRYING STAGE 5: DRY MILLING Change water quantity to x for next batch Y Is the granule size distribution too fine? Granule Size Distribution Measurement Wet Granulation model N Y Comil model: Current parameters acceptable? N Change Comil Parameters
11 Summary and reflections Manufacturing is a customer R&D need to know what is important Output from R&D is choice or flexibility Operations need to understand why there are constraints Being smarter about how R&D deliver Using Quality Risk Management effectively Prioritise and rationalise Maximising opportunities to collect data Using PATs Minimising number of experiments Using DOEs in conjunction with all manufactures Use of models to understand and predict relationships
Q8 and Q8 annex An industry Perspective
Workshop on Implementation of ICH Q8/Q9/Q10 and Other Quality Guidelines Beijing December 2008 Q8 and Q8 annex An industry Perspective Brian Withers, Abbott Laboratories, United Kingdom I attend this conference
More informationConsiGma TM, a platform for continuous processing
ConsiGma TM, a platform for continuous processing GEA Pharma Systems Where Inspiration meets Technology GEA Process Engineering / GEA Pharma Systems ConsiGma TM R&D and Manufacturing platform ConsiGma
More informationICH Q12 (Pharmaceutical Product Lifecycle Management): PMDA Perspective
14 th DIA Japan Annual Meeting 2017 November 12-14, 2017 Tokyo Big Sight Ariake ICH Q12 (Pharmaceutical Product Lifecycle Management): PMDA Perspective Yasuhiro Kishioka, Ph.D. Principal Reviewer Office
More informationAnalytical Methods and Sampling in the New Manufacturing Paradigm a Regulatory Perspective
Analytical Methods and Sampling in the New Manufacturing Paradigm a Regulatory Perspective Dr. Øyvind Holte Norwegian Medicines Agency EMA PAT team/ EDQM PAT working party 15 October, 2014, Heidelberg
More informationSTRATEGIES FOR SUCCESSFUL SCALE-UP USING QUALITY BY DESIGN
STRATEGIES FOR SUCCESSFUL SCALE-UP USING QUALITY BY DESIGN CHRISTOPHER J POTTER ISPE ADVISOR AND CMC CONSULTANT 1 AGENDA Background ICH Guidelines Terms and Definitions Supporting Information ISPE publications
More informationImportance of ICH Guidance in Fulfilling Process Validation Requirements
Importance of ICH Guidance in Fulfilling Process Validation Requirements Presented by: Gamal Amer All rights reserved. Do not copy without permission. Principal 1 Premier Compliance Services, Inc. Process
More informationTechnology Transfer Plays an Increasingly Important Role in Pharmaceutical Quality Systems
Technology Transfer Plays an Increasingly Important Role in Pharmaceutical Quality Systems A robust and secure manufactured product is the desired end result for pharmaceutical companies. Scale-up and
More informationChallenges of Implementation of ICH Q 8
Challenges of Implementation of ICH Q 8 A Regulatory Perspective Dr. Susanne Keitel BioKorea, Seoul, September 2007 Overview of the Presentation ICH Q 8: Background; EU Experience Design Space Associated
More informationQbD/PAT Implementation: The Road to RTR From Science to Compliance
Quality by Design China 2013 April 17-18, 2013 Shanghai, China Pedro Hernandez, PhD 何盼多博士 Senior Director Quality Assurance - China http://www.frontagelab.com pedrohernandez@frontagelab.com.cn Background
More informationTerrence Tougas. Dennis Sandell
Terrence Tougas Boehringer Ingeheim, Ridgefield, CT Dennis Sandell S5 Consulting, Lund, Sweden (c) 2011 Sandell & Tougas 1 Transforming the general concept of Quality into objective, well defined and actionable
More informationImplementation of ICH Q8 and QbD An FDA Perspective
ISPE, Yokohama, Japan June 9, 2006 Implementation of ICH Q8 and QbD An FDA Perspective Chi-wan Chen, Ph.D. Office of New Drug Quality Assessment Center for Drug Evaluation and Research Food and Drug Administration
More informationValue Paper. Are you PAT and QbD Ready? Get up to speed
Value Paper Are you PAT and QbD Ready? Get up to speed PAT and Quality-by-Design As PAT and Quality -by-design (QbD) become an integral part of the regulatory framework, automation group ABB argues more
More informationThe GEA Pharma Solids Center. Improving your products, optimizing your processes, making science work
The GEA Pharma Solids Center Improving your products, optimizing your processes, making science work 2 GEA PHARMA SOLIDS CENTER COMMITTED TO OUR CUSTOMERS With our unparalleled history of expertise in
More informationQuality by Design. Innovate Design Development Create value. Correct definition of QbD and its relation to product and process development
Innovate Development Create value Quality by Correct definition of QbD and its relation to product and process development Dr John Loveluck 42 Technology Ltd +44 1480 302700 john.loveluck@42technology.com
More informationFrom API to Formulated Product
From API to Formulated Product Jean-Marie Geoffroy, PhD Director, Product Development Takeda Global Research & Development 675 N Field Drive Lake Forest, IL 60045 jean-marie.geoffroy@tgrd.com Acknowledgments
More informationThe prospective contribution and the global and integrated approach to pharmaceutical industry s new challenges.
The prospective contribution and the global and integrated approach to pharmaceutical industry s new challenges. Dr. Catherine FRADE Strategic Prospective Director AXELPHARM 22nd Annual EuroMeeting March
More informationAssociation. Innovation in Medicines PDA: A Global. and Manufacturing. David Tainsh, GSK Keith Pugh, MHRA
Innovation in Medicines PDA: A Global and Manufacturing Association David Tainsh, GSK Keith Pugh, MHRA Joint Regulators/Industry QbD Workshop 28-29 January 2014 London, UK Introduction Current State We
More informationICH Q8, 9 & 10 and the Impact on the QP
1 ICH Q8, 9 & 10 and the Impact on the QP Peter H. Gough David Begg Associates phg@david-begg-associates.com 2 A New Approach to Regulation Approach to the regulation of pharmaceuticals is undergoing a
More informationQuality by Design, Clinical Relevance & Lifecycle Considerations
Quality by Design, Clinical Relevance & Lifecycle Considerations Robert Iser Acting Director Office of Process & Facilities / OPQ / CDER IFPAC 2016 1 FDA Quality Related Guidance and Initiatives Initiatives
More informationTechnology to meet the needs of patients around the world
Technology to meet the needs of patients around the world Dr. Michael Thien, Senior Vice President Global Science, Technology and Commercialization Merck & Co., Inc. Our Past Scientific approach applied
More informationPMDA perspective on Quality by Design for pharmaceutical products
PMDA perspective on Quality by Design for pharmaceutical products Junichi Fukuchi, Ph.D. Office of Cellular and Tissue-based Products Pharmaceuticals and Medical Devices Agency (PMDA) Annual conference
More informationProcess Analytical Technology (PAT): A Real Time Quality Assurance
Review Article Process Analytical Technology (PAT): A Real Time Quality Assurance Punita Raj, N. Vishal Gupta* Pharmaceutical Quality Assurance group, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara
More informationGSK s Development of Novel Oral Delivery Technologies Perspectives
GSK s Development of Novel Oral Delivery Technologies Perspectives Mark Wilson Director, PTS, R&D GlaxoSmithKline Pharmaceuticals GSK Established a Technology Incubator To Develop Drug Delivery Systems
More informationInnovative Approaches to Pharmaceutical Development and Manufacturing Seminar Series
CAMO European Pharmaceutical Seminars Jan/Feb 2009 Innovative Approaches to Pharmaceutical Development and Manufacturing Seminar Series The Increasing Need of Multivariate Analysis for Process Understanding
More informationQbD Application in Japan: PMDA Perspective
CMC Strategy Forum Japan 2013 Hotel Okura, Tokyo, Japan, December 9 10, 2013 QbD Application in Japan: PMDA Perspective Yasuhiro Kishioka, PhD. Reviewer Office of Cellular and Tissue based Products Pharmaceuticals
More informationIntroduction. Methods: Spherical Granulation. Shawn Engels, Vector Corporation
DISCUSSION OF PROCESSES WHICH UTILIZE CONICAL ROTOR TECHNOLOGY (SPHERONIZATION OR SPHERICAL GRANULATION, POWDER LAYERING OF ACTIVES OR POLYMERS, CONVENTIONAL SOLUTION/SUSPENSION APPLICATION OF ACTIVES
More informationCERAMIC WHITEWARES TRAINING MODULES
CERAMIC WHITEWARES TRAINING MODULES Our flexible industry-based whitewares training courses have been designed for tableware, tile and sanitaryware manufacturers, as well as retailers and suppliers. The
More informationFEATURES APPLICATIONS. at I F (ma) (ma) MIN. TYP. MAX. MIN. TYP. MAX. MIN. TYP. MAX.
Little Star 1 W Power SMD LED 2783 DESCRIPTION The VLMK71.., VLMR71.., VLMY71.. is one of the most robust and light efficient LEDs in the market. With its extremely high level of brightness and the ultra
More informationDetection and Characterization of Acoustic Signals from a Granulation Process
Detection and Characterization of Acoustic Signals from a Granulation Process Yogesh Gupta*, Terence O Brien*, Ruiyao Gao* *ITT Dublin, Ireland. Yogeshgupta@ieee.org, Terence.Obrien@ittdublin.ie, Ruiyao.Gao@ittdublin.ie
More informationEDQM Conference. Quality of Medicines in a Globalised World: Dreams and Reality
EDQM Conference Quality of Medicines in a Globalised World: Dreams and Reality 14-15 October 2010 Prague, Czech Republic 2010 EDQM, Council of Europe, All rights reserved Plenary Session Dr Moheb M. Nasr
More informationFeedback EMEA / Industry Discussion
Feedback EMEA / Industry Discussion Eli Lilly & Co Ltd Case Study: Use of In-Line Near-Infrared Spectroscopy to Monitor Segregation of a Pharmaceutical Powder Blend in a Tablet Press Martin Diller PhD,
More informationPharmaceutical Manufacturing Technology Centre (PMTC) Detailed Description of Needs Document April 2012
Pharmaceutical Manufacturing Technology Centre (PMTC) Enterprise Ireland & IDA Ireland an industry led, industry driven research programme Detailed Description of Needs Document April 2012 PAGE 1 Contents
More informationLittle Star 1 W Power SMD LED White
2784 DESCRIPTION The VLMW711. is one of the most robust and light efficient LEDs in the market. With its extremely high level of brightness and the ultra low height profile, which is only 1.5 mm are highly
More informationSIZE REDUCTION SYSTEMS
SIZE REDUCTION SYSTEMS CONTROLLED PARTICLE SIZE REDUCTION. PREDICTABLE RESULTS. THE FITZPATRICK COMPANY THE PROCESS COM MI NUTE ( kom noot ) tr. v. Controlled size reduction with predictable and repeatable
More informationFuture of Pharmaceutical Quality and the Path to Get There
Future of Pharmaceutical Quality and the Path to Get There Lawrence Yu, Ph.D. Deputy Director, Office of Pharmaceutical Quality FDA Center for Drug Evaluation and Research INTERPHEX 2018, April 18, 2018,
More informationPERFECT SURFACES WORLDWIDE
A WELCOME FROM THE TECHNOLOGY LEADER in mass finishing Proverbial ingenuity, coupled with German efficiency and a love of perfection, are the best qualifications for developing successful ways of creating
More informationMulti SMD LED RGB FEATURES APPLICATIONS MIN. TYP. MAX. MIN. TYP. MAX. MIN. TYP. MAX.
Multi SMD LED RGB DESCRIPTION 2777 tricolor LEDs is a high brightness device designed for demanding applications in efficiency and uced space. An ideal device in emphasizing visual effects, advertisement,
More informationImplementing Quality Systems
Implementing Quality Systems CGMP By The Sea August 29, 2006 Chris Joneckis, Ph.D. Senior Advisor For CMC Issues Center For Biologics Evaluation And Research Add FDA Bar and Presentation Overview Driving
More informationWorkshop: GRANULATION & TABLETING New requirements for an established technology - robustness, efficiency and quality.
Workshop: GRANULATION & TABLETING New requirements for an established technology - robustness, efficiency and quality. 12 14 April 2016 WHY PARTICIPATE? This workshop on granulation and tableting is a
More informationIR Receiver Module for Light Barrier Systems
IR Receiver Module for Light Barrier Systems TSSP4038 2 3 MECHANICAL DATA Pinning: = OUT, 2 = GND, 3 = V S 6672 FEATURES Low supply current Photo detector and preamplifier in one package Internal filter
More informationChallenges, benefits, case study
hallenges, benefits, case study Pharmaceutical development phases overview The new paradigm for development: Quality by Design (QbD) hallenges Benefits ase study losure and Q&A»»»»»» D. eriani Meet MINITAB,
More informationCurrent Status and Challenges of Bilateral/Multilateral Meetings
Current Status and Challenges of Bilateral/Multilateral Meetings Junko Sato, PhD International Liaison Officer PMDA 26th Annual EuroMeeting 25-27 March 2014 ACV, Vienna Austria Disclaimer The views and
More informationHighbright 0603 ChipLED
Highbright 63 ChipLED DESCRIPTION The new 63 ChipLED series have been designed in the smallest SMD package. This innovative 63 ChipLED technology opens the way to Smaller products of higher performance
More informationTimescales for Change A Look at Innovation in the Pharmaceutical Industry
Timescales for Change A Look at Innovation in the Pharmaceutical Industry 3rd FDA/PQRI Conference on Advancing Product Quality 23 Mar 2017 Robert F. Meyer, Ph.D. Global Pharmaceutical Commercialization
More informationCopyright 2009 Fairchild Books
2/20/12 Copyright 2009 Fairchild Books Beyond Design By Sandra J. Keiser and Myrna B. Garner All rights reserved. No part of this presentation covered by the copyright hereon may be reproduced or used
More informationHigh Performance Computing
High Performance Computing and the Smart Grid Roger L. King Mississippi State University rking@cavs.msstate.edu 11 th i PCGRID 26 28 March 2014 The Need for High Performance Computing High performance
More informationSilicon Phototransistor in 0805 Package
Silicon Phototransistor in 85 Package 243 DESCRIPTION is a high speed silicon NPN epitaxial planar phototransistor in a miniature 85 package for surface mounting on printed boards. The device is sensitive
More informationUltrabright 0402 ChipLED
Ultrabright 42 ChipLED DESCRIPTION The new 42 ChipLED series has been designed in the smallest SMD package. This innovative 42 ChipLED technology opens the way to Smaller products of higher performance
More informationCAFE4DM. Enabling smart factories in the process sector: delivering Industry 4.0 for efficient manufacturing of formulated products
Enabling smart factories in the process sector: delivering Industry 4.0 for efficient manufacturing of formulated products Prof. Philip Martin School of Chemical Engineering and Analytical Science University
More informationCMC Topics and PMDA s activities Yoshihiro Matsuda, Ph.D.
CMC Topics and PMDA s activities Yoshihiro Matsuda, Ph.D. Senior Scientist (for Quality) Pharmaceuticals and Medical Devices Agency (PMDA) MFDS Nov 11, 2016 1 Agenda Introduction of PMDA ICH Q12 QbD assessment
More informationESDA24P140-1U3M. High power transient voltage suppressor. Datasheet. Features. Application. Description
Datasheet High power transient voltage suppressor Features Pin # ID 2 Top view Pin 3 bus (bus pin) 3 3 Bottom view 2 Pin, 2* GND (ground pin) *Pin and Pin 2 must be connected together. Low clamping voltage
More informationInfrared Emitting Diode, 950 nm, GaAs
94 8553 DESCRIPTION is an infrared, 95 nm emitting diode in technology, molded in a PLCC-2 package for surface mounting (SMD). FEATURES Package type: surface mount Package form: PLCC-2 Dimensions (L x
More informationHighbright 0603 ChipLED
Highbright 63 ChipLED DESCRIPTION The new ChipLED series have been designed in the smallest SMD package. This innovative ChipLED technology opens the way to smaller products of higher performance more
More informationDesign & Analysis of Ø40 x 80 Conventional Sugar mill head stock.
From the SelectedWorks of Innovative Research Publications IRP India Summer July 1, 2015 Design & Analysis of Ø40 x 80 Conventional Sugar mill head stock. Santosh Y Salunkhe Available at: https://works.bepress.com/irpindia/374/
More informationQUALITY: BRACKETING AND MATRIXING DESIGNS FOR STABILITY TESTING OF NEW VETERINARY DRUG SUBSTANCES AND MEDICINAL PRODUCTS
VICH GL 45 (QUALITY) BRACKETING AND MATRIXING April 2010 For Implementation at Step 7 QUALITY: BRACKETING AND MATRIXING DESIGNS FOR STABILITY TESTING OF NEW VETERINARY DRUG SUBSTANCES AND MEDICINAL PRODUCTS
More informationVJ 3505 UHF Chip Antenna for Mobile Devices
VJ 355 VJ 355 UHF Chip Antenna for Mobile Devices The company s products are covered by one or more of the following: WO2825262 (A1), US283372 (A1), US283575 (A1), WO28154173 (A1). Other patents pending.
More informationLow Current SMD LED PLCC-2
Low Current SMD LED PLCC-2 VLMC31. 19225 DESCRIPTION These new devices have been designed to meet the increasing demand for low current SMD LEDs. The package of the VLMC31. is the PLCC-2 (equivalent to
More informationSilicon NPN Phototransistor
Silicon NPN Phototransistor VEMT37 DESCRIPTION 9 8553 VEMT37 is a high speed silicon NPN epitaxial planar phototransistor in a miniature PLCC-2 package for surface mounting on printed boards. The device
More informationPROCESS ANALYTICAL TECHNOLOGY (PAT) - AS A CULTURE OF INNOVATION
International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol.1, No.4, pp 1339-1344, Oct-Dec 2009 PROCESS ANALYTICAL TECHNOLOGY (PAT) - AS A CULTURE OF INNOVATION Deepak D. Pokharkar*,
More informationLA-950 Laser Diffraction Analyzer
LA-950 Laser Diffraction Analyzer mark.bumiller@horiba.com Laser Diffraction Particle size 0.01 3000 µm Low End Sensitivity 30, 40, 50, 70 nm latex standards Low End Sensitivity Sensitivity: small particle
More informationEU GMP Evolution or Revolution Scope and drivers for EU GMP changes. August Gordon Farquharson
EU GMP Evolution or Revolution Scope and drivers for EU GMP changes August 2015 Gordon Farquharson EU & PIC/S Harmonisation at IWG level now Slide 2 PharmOut 2015 EU & PIC/S Harmonisation (1) What does
More informationStandard Mini SMD LED
Standard Mini SMD LED DESCRIPTION 19226 The MiniLED series has been designed in a small white SMT package. The feature of the device is the very small package 2.3 mm x 1.3 mm x 1.4 mm. The MiniLED is an
More informationImpact of ICH Q9 and the application of Risk Management
Safeguarding public health Impact of ICH Q9 and the application of Risk Management An inspector s perspective on the impact on inspectional approaches and expectations Ian Thrussell Strategy and Development
More informationSteady-State zone and control chart for process parameters of a powder compactor
Steady-State zone and control chart for process parameters of a powder compactor Non Clinical Statistics Conference Lyon, 28 September 2010 Henri Da-Cruz (*), Cécile Gabaude-Renou (*), Céline Giroud (**),
More informationSilicon Phototransistor in 0805 Package
Silicon Phototransistor in 85 Package TEMT7X1 Vishay Semiconductors 243-1 DESCRIPTION TEMT7X1 is a silicon NPN epitaxial planar phototransistor with daylight blocking filter in a miniature, black 85 package
More informationImplementation of a control loop for a continuous powder mixing process X.J. Zhao a, C. Gatumel a, J.L. Dirion a, H. Berthiaux a, M.
Implementation of a control loop for a continuous powder mixing process X.J. Zhao a, C. Gatumel a, J.L. Dirion a, H. Berthiaux a, M. Cabassud b a Université de Toulouse ; Mines Albi ; UMR CNRS 5302 ; Centre
More informationHigh Speed Infrared Emitting Diode, 850 nm, GaAlAs, DH
High Speed Infrared Emitting Diode, 850 nm, GaAlAs, DH DESCRIPTION is an infrared, 850 nm side looking emitting diode in GaAlAs double hetero (DH) technology with high radiant power and high speed, molded
More informationDual Color Emitting Diodes, 660 nm and 940 nm
Dual Color Emitting Diodes, 660 nm and 940 nm FEATURES Package type: surface mount Package form: square PCB Dimensions (L x W x H in mm): x x 0.87 Peak wavelength: λ p = 660 nm and 940 nm High reliability
More informationIR Receiver Module for Light Barrier Systems
IR Receiver Module for Light Barrier Systems MECHANICAL DATA Pinning: = OUT, 2 = GND, 3 = V S 2 3 6672 APPLICATIONS Reflective sensors for hand dryers, towel or soap dispensers, water faucets, toilet flush
More informationLow Current SMD LED PLCC-2
Low Current SMD LED PLCC-2 VLMA31 19225 DESCRIPTION These new devices have been designed to meet the increasing demand for low current SMD LEDs. The package of the VLMA31 is the PLCC-2 (equivalent to a
More informationMulti SMD LED RGB FEATURES APPLICATIONS. WAVELENGTH (nm) at I F (ma)
Multi SMD LED RGB VLMRGB611.. DESCRIPTION The VLMRGB611.. is a high brightness tricolor LED designed primarily for interior automotive lighting, RGB displays and backlights. It is using the popular 358
More informationHigh Speed Infrared Emitting Diodes, 940 nm, Surface Emitter Technology
High Speed Infrared Emitting Diodes, 940 nm, Surface Emitter Technology 21531 DESCRIPTION As part of the SurfLight TM portfolio, the is an infrared, 940 nm emitting diode based on GaAlAs surface emitter
More informationRISK & RELIABILITY BASED FITNESS FOR SERVICE (FFS) ASSESSMENT FOR SUBSEA PIPELINES By. Ir. Muhd Ashri Mustapha & Dr. Yong BaI.
RISK & RELIABILITY BASED FITNESS FOR SERVICE (FFS) ASSESSMENT FOR SUBSEA PIPELINES By Ir. Muhd Ashri Mustapha & Dr. Yong BaI. June 2011 Hannover All rights reserved. No part of this document may be reproduced,
More informationSilicon PIN Photodiode
Silicon PIN Photodiode 20043- DESCRIPTION is a high speed and high sensitive PIN photodiode. It is a miniature surface mount device (SMD) including the chip with a 0.23 mm 2 sensitive area and a daylight
More informationFT-IR.
FT-IR varian, inc. 610/620-IR ft-ir MICROSCOPY AND IMAGING SoLUTIONS www.varianinc.com VARIAN, INC. Setting the Standard Again When Only the Best Will Do The world leader in molecular spectroscopy innovation
More informationUV SMD LED PLCC-2 FEATURES APPLICATIONS. at I F (ma) (ma) MIN. TYP. MAX. MIN. TYP. MAX. MIN. TYP. MAX.
UV SMD LED PLCC-2 VLMU31 19225 DESCRIPTION The package of the VLMU31 series is the PLCC-2. It consists of a lead frame which is embedded in a white thermoplast. The reflector inside this package is filled
More informationECMF2-0730V12M12. Common mode filter with ESD protection for USB2.0 interface. Applications. Description. Features. Complies with following standards
Common mode filter with ESD protection for USB2.0 interface Datasheet - production data V BUS high power TVS diode: V RM = 13.2 V I PP (8/20 µs): 70 A Very low PCB space consumption Thin package: 0.55
More informationTECH TRANSFER University Joins Industry. Maite Aguado Pharmaceutical Technology PL Synthon Hispania
TECH TRANSFER University Joins Industry Maite Aguado Pharmaceutical Technology PL Synthon Hispania About me.. - Chemical Degree (UAB) / Master In Pharmaceuticals and Related Products(IUCT) / Master In
More informationOur specials. 1st edition MAGIC PLANT.
EN Our specials. 1st edition 2016. MAGIC PLANT. SPECIALS /// 1st edition 2016 4 /// MAGIC PLANT BASIC We introduce you to an innovative product spectrum. Through our specials we will launch a new offer
More informationGranulation & Tableting
Granulation & Tableting GMP Compliance and Technology for the Manufacture of Oral Solid Dosage Forms Solving sticking, capping & lamination problems SPEAKERS: Dr Michael Braun Boehringer Ingelheim Pharma,
More informationSilicon Phototransistor in 0805 Package
Silicon Phototransistor in 85 Package 243-1 DESCRIPTION is a silicon NPN epitaxial planar phototransistor with daylight blocking filter in a miniature, black 85 package for surface mounting. Filter bandwidth
More informationZener Diodes FEATURES
ZPYV9 to ZPY Zener Diodes PRIMARY CHARACTERISTICS PARAMETER VALUE UNIT FEATURES Silicon planar power Zener diodes For use in stabilizing and clipping circuits with high power rating The Zener voltages
More informationDRAG FINISHING UNITS DF SERIES
DRAG FINISHING UNITS DF SERIES PERFECT SURFACES WORLDWIDE 2 THE DRAG FINISHING PROCESS OTEC: WE MAKE THE DIFFERENCE Polishing, deburring, rounding or smoothing: We build drag finishing systems to finish
More informationSilicon PIN Photodiode
Silicon PIN Photodiode DESCRIPTION is a high speed and high sensitive PIN photodiode. It is a small surface mount device (SMD) including the chip with a 0.85 mm 2 sensitive area and a daylight blocking
More informationHigh Speed Infrared Emitting Diode, 940 nm, Surface Emitter Technology
High Speed Infrared Emitting Diode, 94 nm, Surface Emitter Technology 948553 DESCRIPTION As part of the SurfLight TM portfolio, the is an infrared, 94 nm emitting diode based on surface emitter technology
More informationSilicon NPN Phototransistor
TEKT54S Silicon NPN Phototransistor 16733 DESCRIPTION TEKT54S is a silicon NPN phototransistor with high radiant sensitivity, molded in a plastic package with side view lens and daylight blocking filter.
More informationSilicon NPN Phototransistor in, RoHS Compliant, Released for Lead (Pb)-free Solder Process, AEC-Q101 Released
Compliant, Released for Lead (Pb)-free 21568 VEMT22X1 DESCRIPTION VEMT2X1 VEMT2X1 series are silicon NPN epitaxial planar phototransistors with daylight blocking filter in a miniature, black dome lens
More informationSilicon NPN Phototransistor
Silicon NPN Phototransistor DESCRIPTION 7 is a silicon NPN phototransistor with high radiant sensitivity in black, T-1¾ plastic package with base terminal and daylight blocking filter. Filter bandwidth
More informationSilicon PIN Photodiode
BPVNF Silicon PIN Photodiode DESCRIPTION 640- BPVNF is a PIN photodiode with high speed and high radiant sensitivity in black, T-¾ plastic package with daylight blocking filter. Filter bandwidth is matched
More informationRhino r VE/CE Pneumatic Level Detect Modules. Description S S. The assembly detects two conditions during the downward movement of the follower:
Rhino r VE/CE Pneumatic Level Detect Modules Description See Figure 1. Level Detect modules use roller plunger limit switches on guide rails to monitor the distance between the bottom of the follower and
More informationDISCONTINUED PH5502B2NA1-E4. Preliminary. Data Sheet. Ambient Illuminance Sensor DESCRIPTION FEATURES APPLICATIONS. R08DS0038EJ0100 Rev.1.
PH5502B2NA-E4 Ambient Illuminance Sensor DESCRIPTION Preliminary Data Sheet The PH5502B2NA-E4 is an ambient illuminance sensor with a photo diode and current amplifier. This product has spectral characteristics
More informationHigh Speed Infrared Emitting Diode, 830 nm, GaAlAs Double Hetero
High Speed Infrared Emitting Diode, 83 nm, GaAlAs Double Hetero 948553 DESCRIPTION is an infrared, 83 nm emitting diode in GaAlAs double hetero (DH) technology with high radiant power and high speed, molded
More informationHigh Speed Infrared Emitting Diode, 940 nm, GaAlAs Double Hetero
High Speed Infrared Emitting Diode, 94 nm, GaAlAs Double Hetero 21531 DESCRIPTION is an infrared, 94 nm emitting diode in GaAlAs double hetero technology with high radiant power and high speed, molded
More informationEnhance operational efficiency with Advanced Process Control (APC) Integration of APC in SIMATIC PCS 7 SIMATIC PCS 7. Answers for industry.
Enhance operational efficiency with Advanced Control (APC) Integration of APC in SIMATIC PCS 7 SIMATIC PCS 7 Answers for industry. Modern closed-loop control systems in the process industry In today s
More informationPower SMD LED PLCC-2
Power SMD LED PLCC-2 19225 DESCRIPTION The series is an advanced modification of the Vishay series. It is designed to incorporate larger chips, therefore, capable of withstanding a 5 ma drive current.
More informationre:newcell Re-generation of cellulosic fibres from used textiles
Re-generation of cellulosic fibres from used textiles Trailing the paper trail Many similarities between paper and synthetic cellulosic textiles Same raw material Very similar production process Wide range
More informationSilicon PIN Photodiode, RoHS Compliant, Released for Lead (Pb)-free Reflow Soldering, AEC-Q101 Released
Silicon PIN Photodiode, RoHS Compliant, Released for Lead (Pb)-free Reflow Soldering, AEC-Q1 Released 20535_1 DESCRIPTION is a high speed and high sensitive PIN photodiode. It is a miniature surface mount
More informationVLMW712U2U3XV, VLMW712T3U3US, VLMW712T2T3QN
Little Star 1 W Power SMD LED White 20784-1 DESCRIPTION The VLMW712U2U3XV, VLMW712T3U3US, and VLMW712T2T3QN rank among the most robust and light efficient LEDs in the market. Using recent and reliable
More informationHigh Ohmic/High Voltage Metal Film Leaded Resistors
, High Ohmic/High Voltage FEATURES Metal film technology High pulse loading (up to 10 kv) capability Small size (0207/0411) Compatible with lead (Pb)-free and lead containing soldering processes Compliant
More informationAluminum Capacitors Radial Miniature Semi-Professional MARKING
Aluminum Capacitors 047 RMS Fig.1 Component outline. QUICK REFERENCE DATA DESCRIPTION VALUE Nominal case sizes ( D L in mm) 10 12 to 18 35 Rated capacitance range, C R 100 to 10000 μf Tolerance on C R
More information