NSF Investments in Synthetic Biology
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1 National Science Foundation Directorate for Biological Sciences Molecular and Cellular Biosciences Directorate for Engineering Emerging Frontiers in Research and Innovation Chemical Bioengineering Environmental and Transport Systems NSF Investments in Synthetic Biology National Academies of Science October Theresa Good SohiRastegar Friedrich Srienc Susanne von Bodman 1
2 NATIONAL SCIENCE FOUNDATION OFFICE OF DIVERSITY & INCLUSION (ODI) NATIONAL SCIENCE BOARD (NSB) NATIONAL SCIENCE BOARD OFFICE OFFICE OF THE DIRECTOR Deputy Director and Acting Director OFFICE OF THE GENERAL COUNSEL (OGC) OFFICE OF INTERNATIONAL & INTEGRATIVE ACTIVITIES (OIIA) OFFICE OF INSPECTOR GENERAL (OIG) OFFICE OF LEGISLATIVE & PUBLIC AFFAIRS (OLPA) BIOLOGICAL SCIENCES (BIO) COMPUTER & INFORMATION SCIENCE & ENGINEERING (CISE) EDUCATION & HUMAN RESOURCES (EHR) ENGINEERING (ENG) GEOSCIENCES (GEO) MATHEMATICAL & PHYSICAL SCIENCES (MPS) ECONOMIC SCIENCES (SBE) MANAGEMENT (BFA) OFFICE OF INFORMATION & RESOURCE MANAGEMENT (OIRM) Acting Joanna E. Rom DIVISION OF BIOLOGICAL INFRASTRUCTURE (DBI) DIVISION OF COMPUTER & DIVISION OF GRADUATE EDUCATION (DGE) TRANSPORT SYSTEMS (CBET) Acting DIVISION OF ATMOSPHERIC & GEOSPACE SCIENCES (AGS) M DIVISION OF ASTRONOMICAL SCIENCES (AST) DIVISION OF BEHAVIORAL & COGNITIVE SCIENCES (BCS) BUDGET DIVISION (BUD) DIVISION OF ADMINISTRATIVE SERVICES (DAS) Acting DIVISION OF ENVIRONMENTAL BIOLOGY (DEB) Acting DIVISION OF INTEGRATIVE ORGANISMAL SYSTEMS (IOS) DIVISION OF COMPUTING & COMMUNICATION FOUNDATIONS (CCF) DIVISION OF ADVANCED CYBERINFRASTRUCTURE (ACI) DIVISION OF HUMAN RESOURCE DEVELOPMENT (HRD) Acting DIVISION OF RESEARCH ON LEARNING IN FORMAL & INFORMAL SETTINGS (DRL) MECHANICAL & MANUFACTURING INNOVATION (CMMI) COMMUNICATIONS & CYBER SYSTEMS (ECCS) DIVISION OF EARTH SCIENCES (EAR) DIVISION OF OCEAN SCIENCES (OCE) DIVISION OF CHEMISTRY (CHE) Acting DIVISION OF MATERIALS RESEARCH (DMR) DIVISION OF SOCIAL & ECONOMIC SCIENCES (SES) NATIONAL CENTER FOR SCIENCE AND ENGINEERING STATISTICS (NCSES) DIVISION OF ACQUISITION AND COOPERATIVE SUPPORT (DACS) DIVISION OF FINANCIAL MANAGEMENT (DFM) DIVISION OF INFORMATION SYSTEMS (DIS) DIVISION OF HUMAN RESOURCE MANAGEMENT (HRM) DIVISION OF MOLECULAR & CELLULAR BIOSCIENCES (MCB) DIVISION OF INFORMATION & INTELLIGENT SYSTEMS (IIS) DIVISION OF UNDERGRADUATE EDUCATION (DUE) Acting DIVISION OF ENGINEERING EDUCATION & CENTERS (EEC) DIVISION OF POLAR PROGRAMS (PLR) DIVISION OF MATHEMATICAL SCIENCES (DMS) DIVISION OF GRANTS & AGREEMENTS (DGA) OFFICE OF EMERGING FRONTIERS (EF) Acting DIVISION OF INDUSTRIAL INNOVATION & PARTNERSHIPS (IIP) DIVISION OF PHYSICS (PHY) DIVISION OF INSTITUTION & AWARD SUPPORT (DIAS) OFFICE OF MULTIDISCIPLINARY ACTIVITIES (OMA) LARGE FACILITIES OFFICE OFFICE OF EMERGING FRONTIERS IN RESEARCH & INNOVATION (EFRI) Deputy Director Acting Senior Advisor June 2013 NSF Mission: To promote the progress of science; to advance the national health prosperity and welfare; and to secure the national defense
3 MPS 21% ENG ERC Synthetic Biology Funding at NSF (~$55M /year) SynBERC CBiRC CBET IIP- Core program SBIR STTR CISE SBE EHR MPS (CHE PHY) Other 6% IIP 17% BIO ERC 34% MCB DBI IOS Core SAVI Informatics Education DBI 11% BIO 27% ENGG 46% CBET 46% IOS 1% MCB 88%
4 Synthetic Biology NSF Funding NSF investments in Synthetic Biology have been predominantly driven through unsolicited proposals by the research community SynBERC Largest investment by NSF established in 2006 EFRI IDEAS lab Joint NSF/EPSRC Sandpit on Synthetic Biology CBET/BBBE Unsolicited proposals MCB/Systems and Synthetic Biol. Cluster Unsolicited proposals SBIR/STTR Unsolicited proposals INSPIRE SAVI Science Across Virtual Institutes Yeast Chromosome Synthesis and Analysis; partnership between US China Europe and India
5 Challenges Agency Sees for the Focus Areas It Supports NSF mission is to advance science and ensure education and training of workforce translate advances in science to ensure national prosperity (i.e.job creation) Advance of science: $$$$$$ Development of fundamental technologies Research infrastructure (repositories data storage who funds it what are the standards) International collaboration/competition Concentration of resources vs democratization of science Development in organisms other than E. coli How do you proceed safely ethically with public trust (perceived versus actual risk) Education Discipline specific versus interdisciplinary training Curriculum resources Translation to Industry Job creation Robustness of systems Economics uncertain IP regulatory landscape
6 Issues for the forum to explore Coordination of funding/collaboration to better leverage resources between agencies Address perceived versus actual risk of technology Is there a need for standard development for the purpose of developing respositories for data How will we fund national/international research infrastructure that benefits all
7 US Synthe c Biology Roadmap Coordina on Group Reps. from Academia Industry Social Ethical and Environmental Scien sts Policy Makers others PRIORITY CONSIDERATION: DEVELOP A NATIONAL STRATEGY / ROADMAP FOR SYNBIO RESEARCH/EDUCATION/INDUSTRIAL DEVELOPMENT SOCIETAL EETHICAL AND POLICY ISSUES
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